The Talapoosa Mine, named for the Tallapoosa tribe of Creek Indians and associated river in Alabama, was discovered as early as 1863 by prospectors from Virginia City. The Knight (later Talapoosa) District was organized, but it wasn't until after the turn of the century that any major work began. In 1905, that principal property was acquired by the Talapoosa Company, and for a while it was worked by leasers. By 1926, Talapoosa was equipped with a 25-ton concentration mill. Most production occurred between 1938 and 1942, and in total over $300,000 in gold and silver was shipped to the Dayton Consolidated Mill at Silver City. The mill and most remaining camp buildings were lost to mining or reclamation in the 1980s or early 1990s, and exploratory work is ongoing as of 2023.