The Pamlico Mine's largest recorded period of production was during the 1870s and 1880s, when it was estimated to have produced $500,000 in gold. In 1902, it was acquired by the Consolidated Esmeralda Mines Company, with ex-Governor R.K. Colcord as Superintendent. Under Colcord, 1904 brought a new mill to Pamlico, with a pipeline from Cottonwood Canyon. How long the mill operated is unclear, but leasers worked the mine through at least World War I.

In 1919, Fred R. Dodge and his Goldbug Consolidated Mines Co. took a bond and lease on the Pamlico and nearby La Panta mines as well as the aforementioned mill. The Company spent $25,000 on a 20-stamp quartz mill with a capacity of 25 tons/day; whether this was a new mill or a remodel of the previous mill is unknown. Meanwhile, George Box installed his own mill to treat ore from his mine at Neversweat Canyon. Work continued through the 1920s and in 1928, Box's mill was purchased and relocated to the Buckskin district in Lyon County.

Mr. Dodge and his mill remained into the 1930s. In 1931, he built an arrastra to treat his ore, citing drought preventing him from operating the stamp mill. By January of the next year, he announced plans to restart the mill after a promising winter; unfortunately he died at Pamlico before the month's end. Lessee work continued, and in 1937 the new Pamlico Mining Company took over the mine and mill, with plans to increase milling capacity to 150 tons/day by adding a ball mill and recovery system, though it seems these plans never came to fruition as the 20-stamp mill was referred to as "outmoded" just two years later when the then-closed Pamlico property was again purchased, this time by the Banner Development Company. It seems that little development or production was actually done in subsequent years, but by the late 2010s interest in Pamlico was renewed and the Newrange Gold Corp. has conducted exploratory work.

See Also
La Panta