Granville W. Huffaker arrived in the Truckee Meadows in 1858, driving 500 head of cattle and establishing his ranch the next year. By 1862, a small settlement formed and an unofficial post office opened. A stage line, operated by Langton & Co.'s Pioneer Express, served the small community, and by the time Nevada became a state Huffaker's was home to 300 people, hotels, and more. A handsome schoolhouse was constructed in 1867 or 68, and when the town was reached by the Virginia & Truckee Railroad in 1872, a produce station was established. In 1875, Huffaker's also became the terminus of the Pacific Wood, Lumber & Flume Co.'s six-mile flume from the Tahoe Basin.

After the turn of the century, the Huffaker estate was purchased by rancher George Holcomb. Today the old homestead and community have been absorbed by Reno's newer developments, but the ranch house, schoolhouse, and a small cemetery still remain.