Mottsville was the name of a settlement that developed around the homestead of Hiram Mott and his son Israel, who arrived in the Carson Valley in 1851. Israel Mott's wife, Eliza Ann (née Middaugh), was the first white woman to settle in the area. Mrs. Mott would open the first school in Nevada in 1854, which was held in her kitchen. In 1857, their third child died and was buried nearby, in what later became the Mottsville Cemetery.

The community evidently never achieved any prominence, though the name is still infrequently used. The cemetery and old schoolhouse remain, and Mottsville Lane connects the community to Minden and Gardnerville.